It’s just a note that I hope, it would help me to be a little bit smarter. Data base on whatever I can find and put it all together, it’s just an outline.
Fluoroquinolone Antimicrobial Drugs
[ciprofloxacin (marketed as Cipro and generic ciprofloxacin), ciprofloxacin extended release (marketed as Cipro XR and Proquin XR), gemifloxacin (marketed as Factive), levofloxacin (marketed as Levaquin), moxifloxacin (marketed as Avelox), norfloxacin (marketed as Noroxin), and ofloxacin (marketed as Floxin and generic ofloxacin
FDA ALERT [7/8/2008]: Fluoroquinolones are associated with an increased risk of tendinitis and tendon rupture. This risk is further increased in those over age 60, in kidney, heart, and lung transplant recipients, and with use of concomitant steroid therapy. Physicians should advise patients, at the first sign of tendon pain, swelling, or inflammation, to stop taking the fluoroquinolone, to avoid exercise and use of the affected area, and to promptly contact their doctor about changing to a non-fluoroquinolone antimicrobial drug
January 10, 2009 at 5:25 PM
Posted 01/31/2008] FDA informed healthcare professionals that the Agency has analyzed reports of suicidality (suicidal behavior or ideation) from placebo-controlled clinical studies of eleven drugs used to treat epilepsy as well as psychiatric disorders, and other conditions. In the FDA’s analysis, patients receiving antiepileptic drugs had approximately twice the risk of suicidal behavior or ideation (0.43%) compared to patients receiving placebo (0.22%). The increased risk of suicidal behavior and suicidal ideation was observed as early as one week after starting the antiepileptic drug and continued through 24 weeks. The results were generally consistent among the eleven drugs. The relative risk for suicidality was higher in patients with epilepsy compared to patients who were given one of the drugs in the class for psychiatric or other conditions.
Healthcare professionals should closely monitor all patients currently taking or starting any antiepileptic drug for notable changes in behavior that could indicate the emergence or worsening of suicidal thoughts or behavior or depression.
The drugs included in the analyses include (some of these drugs are also available in generic form):
•Carbamazepine (marketed as Carbatrol, Equetro, Tegretol, Tegretol XR)
•Felbamate (marketed as Felbatol)
•Gabapentin (marketed as Neurontin)
•Lamotrigine (marketed as Lamictal)
•Levetiracetam (marketed as Keppra)
•Oxcarbazepine (marketed as Trileptal)
•Pregabalin (marketed as Lyrica)
•Tiagabine (marketed as Gabitril)
•Topiramate (marketed as Topamax)
•Valproate (marketed as Depakote, Depakote ER, Depakene, Depacon)
•Zonisamide (marketed as Zonegran)
Although the 11 drugs listed above were the ones included in the analysis, FDA expects that the increased risk of suicidality is shared by all antiepileptic drugs and anticipates that the class labeling changes will be applied broadly. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2008/safety08.htm#Antiepileptic and http://www.fda.gov/cder/drug/InfoSheets/HCP/antiepilepticsHCP.htm.
January 23, 2009 at 11:58 AM
Cox-2 inhibitors-Lessons in Drug Safety
http://blog.evidenceinmotion.com/evidence/files/psalty_furberg.%20COX,%202%20drug%20safty.NEJM.06.pdf